Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long
noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how …

Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

The dual effects of reactive oxygen species (ROS) on living organisms have become a hot
research topic in the biomedical field. Excessive ROS triggers oxidative imbalances in the …

Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Cadmium is one of the most toxic metal compounds found in the environment. It is well
established that Cd induces hepatotoxicity in humans and multiple animal models …

SIRT1, an NAD‐dependent deacetylase, plays a role in regulation of autophagy. SIRT1
increases mitochondrial function and reduces oxidative stress, and has been linked to age …

The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by
the development of several experimental anticancer‐and anti‐ischaemia (stroke or …

Alpha‐ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical
role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the …