Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling
platforms that drive cellular transformation upon integrin-dependent adhesion and growth …

Overwhelming) are a set of key stress-responsive kinases that mediate cell apoptosis, which
is an important process for tumor suppression. However, JNKs have also been implicated in …

Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is
derived from the developing sympathetic nervous system. Clinical phenotypes range from …

Dysregulation of the G1/S transition in the cell cycle contributes to tumor development. The
oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this …

Osteosarcomas are copy number alteration (CNA)–rich malignant bone tumors. Using
microarrays, fluorescence in situ hybridization, and quantitative PCR, we characterize a …

Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective
retinal angiogenesis and associated complications that can result in vision loss. Defective …

Oxidative stress plays an important role in alcohol-induced inflammation and liver injury.
Relatively less is known about how Kupffer cells respond to oxidative stress-induced …

Background: Rhabdomyosarcomas (RMSs) are primarily paediatric sarcomas that resemble
developing skeletal muscle. Our aim was to determine the effects of microRNAs (miRNA) …

The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many
physiological processes including inflammatory responses, macrophages, cell proliferation …

Rhabdomyosarcoma (RMS) encompasses a heterogeneous group of tumors with striated
muscle differentiation. RMSs are classified as alveolar, embryonal, spindle cell/sclerosing …