Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside …
PJ Berti, JAB McCann - Chemical reviews, 2006 - ACS Publications
This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
Structure and function of S-adenosylhomocysteine hydrolase
MA Turner, X Yang, D Yin, K Kuczera… - Cell biochemistry and …, 2000 - Springer
In mammals, S-adenosylhomocysteine hydrolase (AdoHcyase) is the only known enzyme to
catalyze the breakdown of S-adenosylhomocysteine (AdoHcy) to homocysteine and …
catalyze the breakdown of S-adenosylhomocysteine (AdoHcy) to homocysteine and …
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
P Belenky, FG Racette, KL Bogan, JM McClure… - Cell, 2007 - cell.com
Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …
Enzymatic transition states and drug design
VL Schramm - Chemical reviews, 2018 - ACS Publications
Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength
MA Turner, CS Yuan, RT Borchardt… - Nature Structural …, 1998 - nature.com
S-Adenosylhomocysteine (AdoHcy) hydrolase regulates all adenosylmethionine-(AdoMet)
dependent transmethylations by hydrolyzing the potent feedback inhibitor AdoHcy to …
dependent transmethylations by hydrolyzing the potent feedback inhibitor AdoHcy to …
A genetic screen to isolate type III effectors translocated into pepper cells during Xanthomonas infection
JA Roden, B Belt, JB Ross… - Proceedings of the …, 2004 - National Acad Sciences
The bacterial pathogen Xanthomonas campestris pv. vesicatoria (Xcv) uses a type III
secretion system (TTSS) to translocate effector proteins into host plant cells. The TTSS is …
secretion system (TTSS) to translocate effector proteins into host plant cells. The TTSS is …
Catalysis by nucleoside hydrolases
W Versées, J Steyaert - Current Opinion in Structural Biology, 2003 - Elsevier
Nucleoside hydrolases cleave the N-glycosidic bond of ribonucleosides. Because of their
vital role in the protozoan purine salvage pathway, nucleoside hydrolases from parasitic …
vital role in the protozoan purine salvage pathway, nucleoside hydrolases from parasitic …
Nucleoside hydrolase from Leishmania major: cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-Å crystal structure
W Shi, VL Schramm, SC Almo - Journal of Biological Chemistry, 1999 - ASBMB
Protozoan parasites lack the pathway of thede novo synthesis of purines and depend on
host-derived nucleosides and nucleotides to salvage purines for DNA and RNA synthesis …
host-derived nucleosides and nucleotides to salvage purines for DNA and RNA synthesis …
Transition state analysis using multiple kinetic isotope effects: mechanisms of enzymatic and non-enzymatic glycoside hydrolysis and transfer
PJ Berti, KSE Tanaka - Advances in Physical Organic Chemistry, 2002 - books.google.com
This chapter addresses both the principles and practice of transition state (TS# 1) analysis
and recent advances in our understanding of hydrolysis and glycosyl transfer reactions of N …
and recent advances in our understanding of hydrolysis and glycosyl transfer reactions of N …
Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: Structure and glycosylase mechanism revisited
G Xiao, M Tordova, J Jagadeesh… - Proteins: Structure …, 1999 - Wiley Online Library
The DNA repair enzyme uracil DNA glycosylase (UDG) catalyzes the hydrolysis of
premutagenic uracil residues from single‐stranded or duplex DNA, producing free uracil and …
premutagenic uracil residues from single‐stranded or duplex DNA, producing free uracil and …