Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Virulence Factors in Hypervirulent Klebsiella pneumoniae

J Zhu, T Wang, L Chen, H Du - Frontiers in microbiology, 2021 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the
Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae …

Hypervirulent klebsiella pneumoniae

TA Russo, CM Marr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Hypervirulent K. pneumoniae (hvKp) is an evolving pathotype that is more virulent than
classical K. pneumoniae (cKp). hvKp usually infects individuals from the community, who are …

An overview of anti-eukaryotic T6SS effectors

J Monjarás Feria, MA Valvano - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine
employed by many Gram-negative bacterial species to translocate, in a contact-dependent …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

TWF Lung, D Charytonowicz, KG Beaumont, SS Shah… - Cell metabolism, 2022 - cell.com
K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated
pneumonia. However, it remains unclear how it causes protracted courses of infection in …

Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone

L Villa, C Feudi, D Fortini, S Brisse… - Microbial …, 2017 - microbiologyresearch.org
The global spread of Klebsiella pneumoniae producing Klebsiella pneumoniae
carbapenemase (KPC) has been mainly associated with the dissemination of high-risk …

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

D Storey, A McNally, M Åstrand… - PLoS …, 2020 - journals.plos.org
Klebsiella pneumoniae is recognized as an urgent threat to human health due to the
increasing isolation of multidrug resistant strains. Hypervirulent strains are a major concern …

Clinical and laboratory insights into the threat of hypervirulent Klebsiella pneumoniae

X Han, J Yao, J He, H Liu, Y Jiang, D Zhao… - International Journal of …, 2024 - Elsevier
Hypervirulent Klebsiella pneumoniae (hvKP) typically causes severe invasive infections
affecting multiple sites in healthy individuals. In the past, hvKP was characterized by a …

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

LMS Lery, L Frangeul, A Tomas, V Passet, AS Almeida… - BMC biology, 2014 - Springer
Background Klebsiella pneumoniae strains are pathogenic to animals and humans, in which
they are both a frequent cause of nosocomial infections and a re-emerging cause of severe …