The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Transcription factors of the MYC family are deregulated in the majority of all human cancers.
Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development …

The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …

Growth-promoting signaling molecules, including the mammalian target of rapamycin
complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells required to …

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …

Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …