The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and
elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can …

Transcription factors of the Rel/NF-κB family are activated in response to signals that lead to
cell growth, differentiation, and apoptosis, and these proteins are critical elements involved …

Inflammation is a salutary response to insult or injury that normally resolves with no
detriment to the host. While the mechanisms and mediators that regulate the onset of …

Apoptosis induced by p53 has been proposed to involve activation of the transcription factor
NF-κB. Here we describe the novel molecular mechanism through which p53 and DNA …

Following infection, naïve CD8+ T cells bearing pathogen-specific T cell receptors (TCRs)
differentiate into a mixed population of short-lived effector and long-lived memory T cells to …

Protozoan parasites which reside inside a host cell avoid direct destruction by the immune
system of the host. The infected cell, however, still has the capacity to counteract the …

Cells sense and respond to extracellular factors via receptors on the cell surface that trigger
intracellular signaling pathways. The signals received by the receptors on hematopoietic …

The Rel/NF-κB family of transcription factors has been implicated in the regulation of genes
involved in immune and inflammatory responses, and of processes such as cell survival …

Activation-induced cell death (AICD), which results from the interaction between Fas and
Fas ligand, is responsible for maintaining tolerance to self-antigen. A defect in AICD may …