Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

Ferritin nanocage based delivery vehicles: From single-, co-to compartmentalized-encapsulation of bioactive or nutraceutical compounds

H Chen, X Tan, X Han, L Ma, H Dai, Y Fu… - Biotechnology Advances, 2022 - Elsevier
Bioactive or nutraceutical ingredients have been widely used in pursuit of health and well-
being. However, the environmental instability, poor solubility and bioavailability, and …

Engineered metallacycle‐based supramolecular Photosensitizers for effective Photodynamic Therapy

L Tu, C Li, X Xiong, J Hyeon Kim, Q Li, L Mei… - Angewandte …, 2023 - Wiley Online Library
Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted
increasing attention in biomedicine, their clinical translation is still hindered by their inherent …

Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium (II) Metallacycle

L Tu, C Li, Q Ding, A Sharma, M Li, J Li… - Journal of the …, 2024 - ACS Publications
Though immunogenic cell death (ICD) has garnered significant attention in the realm of
anticancer therapies, effectively stimulating strong immune responses with minimal side …

[HTML][HTML] Bioconjugation of the gold drug auranofin to human ferritin yields a potent cytotoxin

L Cosottini, L Massai, V Ghini, S Zineddu, A Geri… - Journal of Drug Delivery …, 2023 - Elsevier
Ferritin may serve as a nanocarrier for the selective delivery of anticancer metallodrugs.
Here, we have prepared and characterized a well-defined conjugate between the gold drug …

Ruthenium (II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under …

GE Giacomazzo, L Conti, C Fagorzi, M Pagliai… - Inorganic …, 2023 - ACS Publications
Ruthenium (II) polypyridyl complexes (RPCs) are gaining momentum in photoactivated
chemotherapy (PACT), thanks to the possibility of overcoming the classical reliance on …

Unlocking the Power of Human Ferritin: Enhanced Drug Delivery of Aurothiomalate in A2780 Ovarian Cancer Cells

L Cosottini, A Geri, V Ghini, M Mannelli… - Angewandte …, 2024 - Wiley Online Library
Aurothiomalate (AuTM) is an FDA‐approved antiarthritic gold drug with unique anticancer
properties. To enhance its anticancer activity, we prepared a bioconjugate with human …

Multifaceted Applications of Ferritin Nanocages in Delivering Metal Ions, Bioactive Compounds, and Enzymes: A Comprehensive Review

J Hu, X Sha, Y Li, J Wu, J Ma, Y Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Ferritin, a distinctive iron-storage protein, possesses a unique cage-like nanoscale structure
that enables it to encapsulate and deliver a wide range of biomolecules. Recent advances …

Ruthenium (II) polypyridyl complexes with π-expansive ligands: synthesis and cubosome encapsulation for photodynamic therapy of non-melanoma skin cancer

GE Giacomazzo, M Schlich, L Casula… - Inorganic Chemistry …, 2023 - pubs.rsc.org
In photodynamic therapy (PDT), Ru (II) polypyridyl complexes (RPCs) featuring the popular
π-expansive benzo [i] dipyrido [3, 2-a: 2′, 3′-c] phenazine (dppn) ligand have attracted …

[HTML][HTML] 19F: A small probe for a giant protein

L Cosottini, S Zineddu, L Massai, V Ghini… - Journal of Inorganic …, 2023 - Elsevier
Herein we describe a method for the efficient production (∼ 90% fluorination) of 5-F-Trp
human H ferritin via the selective incorporation of 19 F into the side chain of W93 using 5 …