Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease

Z Liu, R Ulrich vonBargen, AL Kendricks… - Nature …, 2023 - nature.com
Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Central role of metabolism in Trypanosoma cruzi tropism and Chagas disease pathogenesis

Z Liu, R Ulrich vonBargen, LI McCall - Current opinion in microbiology, 2021 - Elsevier
Highlights•Trypanosoma cruzi parasites and Chagas disease show specific
tropism.•Metabolism is implicated in T. cruzi parasite tropism and Chagas disease …

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

G Kwakye-Nuako, CE Middleton, LI McCall - PLoS Pathogens, 2024 - journals.plos.org
Small molecules (less than 1,500 Da) include major biological signals that mediate host-
pathogen-microbiome communication. They also include key intermediates of metabolism …

Persistent Biofluid Small-Molecule Alterations Induced by Trypanosoma cruzi Infection Are Not Restored by Parasite Elimination

DA Dean, J Roach, R Ulrich vonBargen… - ACS Infectious …, 2023 - ACS Publications
Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …

Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

E Hossain, S Khanam, DA Dean, C Wu… - Science …, 2020 - science.org
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa,
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …

Bacillus coagulans XY2 ameliorates copper-induced toxicity by bioadsorption, gut microbiota and lipid metabolism regulation

Y Gao, T Yu, F Ai, C Ji, Y Wu, X Huang, X Zheng… - Journal of Hazardous …, 2023 - Elsevier
Excessive copper pollutes the environment and endangers human health, attracting plenty
of global attention. In this study, a novel strain named Bacillus coagulans XY2 was …

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease

DA Dean, G Gautham, JL Siqueira-Neto… - PLoS Neglected …, 2021 - journals.plos.org
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen
neglected tropical diseases. CD is a vector-borne disease transmitted by triatomines, but CD …

Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology

K Hoffman, Z Liu, E Hossain, ME Bottazzi… - ACS infectious …, 2021 - ACS Publications
Chronic Chagasic cardiomyopathy (CCC) is a Neglected Tropical Disease caused by the
parasite Trypanosoma cruzi. The pathognomonic findings in symptomatic CCC patients and …

Fat tissue regulates the pathogenesis and severity of cardiomyopathy in murine chagas disease

K Lizardo, JP Ayyappan, N Oswal… - PLoS neglected …, 2021 - journals.plos.org
Chronic Chagas cardiomyopathy (CCC) caused by a parasite Trypanosoma cruzi is a life-
threatening disease in Latin America, for which there is no effective drug or vaccine. The …

Metabolomic profiling of end-stage heart failure secondary to chronic Chagas cardiomyopathy

ML Díaz, K Burgess, R Burchmore, MA Gómez… - International Journal of …, 2022 - mdpi.com
Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe clinical form of
chronic Chagas disease, representing one of the leading causes of morbidity and mortality …