The widespread use of antibiotics in the past 80 years has saved millions of human lives,
facilitated technological progress and killed incalculable numbers of microbes, both …

Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …

Clinically significant antibiotic resistance has evolved against virtually every antibiotic
deployed. Yet the development of new classes of antibiotics has lagged far behind our …

The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

The emergence and increasing prevalence of bacterial strains that are resistant to available
antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-
negative pathogens with a unique virulence mechanism enabling them to inject bacterial …

Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …

This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Antibiotic resistance is a problem that continues to challenge the healthcare sector. In
particular, multidrug resistance is now common in familiar pathogens such as …

The extreme pH and protease-rich environment of the upper gastrointestinal tract is a major
obstacle facing orally-administered protein therapeutics, including antibodies. Through …