Somatic structural variants (SVs) are widespread in cancer, but their impact on disease
evolution is understudied due to a lack of methods to directly characterize their functional …

The adaptive immune system is responsible for generating immunological response and
immunological memory. Regulation of adaptive immunity including B cell and T cell biology …

ATM (ataxia-telangiectasia mutated) is a PI3K-like kinase best known for its role in the DNA
damage response (DDR), especially after double-strand breaks. Mutations in the ATM gene …

Preferentially expressed antigen in melanoma (PRAME) is the best characterized member of
the PRAME family of leucine-rich repeat (LRR) proteins. Mammalian genomes contain …

The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma
(BL) are highly aggressive lymphomas with poor clinical outcome. High-resolution structural …

Multiple myeloma (MM) patients commonly present abnormal expression of cancer–testis
antigens, which may serve as immunotherapeutic targets and prognostic factors. We …

The identification of driver mutations is fundamental to understanding oncogenesis.
Although genes frequently mutated in B-cell lymphoma have been identified, the search for …

Background Characteristic genomic abnormalities in patients with B cell chronic lymphocytic
leukemia (CLL) have been shown to provide important prognostic information. Fluorescence …

In recent years, emerging evidence has suggested that noncoding RNAs (ncRNAs)
participate in nearly every aspect of biological processes and play a crucial role in the …

The impact of genetic aberrations on rituximab-based therapeutic regimens has been
intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus …