Preeclampsia, one of the most enigmatic complications of pregnancy, is considered a
pregnancy-specific disorder caused by the placenta and cured only by delivery. This article …

Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia is characterized by new-onset hypertension and proteinuria at≥ 20 weeks of
gestation. In the absence of proteinuria, hypertension together with evidence of systemic …

Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care
and self-management to restrict complications, such as obesity, kidney damage and …

Background Preeclampsia is associated with placental ischemia/hypoxia and secretion of
soluble fms-like tyrosine kinase 1 and soluble endoglin into the maternal circulation. This …

High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …

Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our
understanding of the complex interactions among their respective disease pathways …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Background Failure of physiologic transformation of spiral arteries has been reported in
preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact …