The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian
brain. Each isoform consists of five homologous or identical subunits surrounding a central …

Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years. It
has long been recognized that barbiturates act by prolonging and potentiating the action of γ …

Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …

Like other classes of treatments described in this issue's section, neuroactive steroids have
been studied for decades but have risen as a new class of rapid-acting, durable …

By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes,
such as responses to stress and development. Excessive stress affects their biosynthesis …

A potential link between GABRD encoding the δ subunit of extrasynaptic GABAA receptors
and neurodevelopmental disorders has largely been disregarded due to conflicting …

A successful pregnancy requires multiple adaptations in the mother's brain that serve to
optimise foetal growth and development, protect the foetus from adverse prenatal …

Wu, Pharmaceuticals (2009) 2: 77-81. Jiang. X., et al., Neurosteroid analogues. 9.
Conformationally constrained pregnanes: structure-activity studies of 13.24-cyclo 18, 21 …

γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric
chloride channels responsible for the adult brain's primary inhibition. In specific brain cells …