In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …

Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage
Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This …

Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …

Completion of genome duplication is challenged by structural and topological barriers that
impede progression of replication forks. Although this can seriously undermine genome …

Successful DNA replication and packaging of newly synthesized DNA into chromatin are
essential to maintain genome integrity. Defects in the DNA template challenge genetic and …

PRDM9 directs human meiotic crossover hot spots to intergenic sequence motifs, whereas
budding yeast hot spots overlap regions of low nucleosome density (LND) in gene …