Heart donation and preservation: historical perspectives, current technologies, and future directions

NR Hess, LA Ziegler, DJ Kaczorowski - Journal of Clinical Medicine, 2022 - mdpi.com
Heart transplantation has become the accepted treatment for advanced heart failure, with
over 4000–5000 performed in the world annually. Although the number of yearly transplants …

[HTML][HTML] Normothermic regional perfusion is an emerging cost-effective alternative in donation after circulatory death (DCD) in heart transplantation

E Alamouti-Fard, P Garg, IJ Wadiwala, JH Yazji… - Cureus, 2022 - ncbi.nlm.nih.gov
In donation after circulatory death (DCD) organ transplantation, normothermic regional
perfusion (NRP) restores oxygenated blood flow following cardiac arrest and reverses warm …

The unified brain-based determination of death conceptually justifies death determination in DCDD and NRP protocols

JL Bernat - The American Journal of Bioethics, 2024 - Taylor & Francis
Organ donation after the circulatory determination of death requires the permanent
cessation of circulation while organ donation after the brain determination of death requires …

Challenges to brain death in revising the Uniform Determination of Death Act: the UDDA revision series

JL Bernat - Neurology, 2023 - AAN Enterprises
Brain death, more recently called death determination by neurologic criteria, 1 is at the
nexus of current controversy as the US Uniform Law Commission (ULC) seeks to revise the …

Ethical and equity guidance for transplant programs considering thoracoabdominal normothermic regional perfusion (TA-NRP) for procurement of hearts

DM Dudzinski, JD Pal, JN Kirkpatrick - The American Journal of …, 2024 - Taylor & Francis
Donation after circulatory determination of death (DCDD) is an accepted practice in the
United States, but heart procurement under these circumstances has been debated …

Understanding the brain-based determination of death when organ recovery is performed with DCDD in situ normothermic regional perfusion

JL Bernat, B Domínguez-Gil, AK Glazier… - …, 2023 - journals.lww.com
The brain-based determination of death (“brain death”) is now widely accepted throughout
the world. It states that the irreversible cessation of brain functions is the fundamental …

Normothermic regional perfusion requires careful ethical analysis before adoption into donation after circulatory determination of death

H Peled, S Mathews, D Rhodes, JL Bernat - Critical care medicine, 2022 - journals.lww.com
We believe that normothermic regional perfusion (NRP) requires careful ethical evaluation
before its widespread incorporation into donation after circulatory determination of death …

Restoring the organism as a whole: Does NRP resurrect the dead?

EJN Busch - The American Journal of Bioethics, 2024 - Taylor & Francis
The introduction of normothermic regional perfusion (NRP) in controlled donation after
circulatory determination of death (cDCDD) protocols is by some regarded as controversial …

Clinical xenotransplantation seems close: Ethical issues persist

JW Entwistle, RM Sade, DH Drake - Artificial Organs, 2022 - Wiley Online Library
Scientific barriers that have prevented successful xenotransplantation are being breached,
yet many ethical issues remain. Some are broad issues that accompany the adoption of …

Association of procurement technique with organ yield and cost following donation after circulatory death

SS Bakhtiyar, TE Maksimuk, J Gutowski, SY Park… - American Journal of …, 2024 - Elsevier
Donation after circulatory death (DCD) could account for the largest expansion of the donor
allograft pool in the contemporary era. However, the organ yield and associated costs of …