Immune response to dengue and Zika

A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Congenital viral infection: traversing the uterine-placental interface

L Pereira - Annual review of virology, 2018 - annualreviews.org
Why certain viruses cross the physical barrier of the human placenta but others do not is
incompletely understood. Over the past 20 years, we have gained deeper knowledge of …

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

AJ Hirsch, VHJ Roberts, PL Grigsby, N Haese… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth
restriction and fetal central nervous system malformations, which are outcomes broadly …

[HTML][HTML] Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

B Cao, LA Parnell, MS Diamond… - Journal of Experimental …, 2017 - rupress.org
Zika virus (ZIKV) infection during pregnancy leads to devastating fetal outcomes, including
intrauterine growth restriction and microcephaly. Greater understanding of mechanisms …

The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface

H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …

[HTML][HTML] Gestational stage and IFN-λ signaling regulate ZIKV infection in utero

BW Jagger, JJ Miner, B Cao, N Arora, AM Smith… - Cell host & …, 2017 - cell.com
Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early
stages of pregnancy, its basis remains undefined. Using established type I interferon (IFN) …

Features of human decidual NK cells in healthy pregnancy and during viral infection

N Jabrane-Ferrat - Frontiers in immunology, 2019 - frontiersin.org
The hallmark of human early pregnancy is the accumulation of a unique population of
Natural Killer (dNK) cells at the main maternal-fetal interface, the decidua basalis. dNK cells …

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface

J Gouilly, Q Chen, J Siewiera, G Cartron, C Levy… - Nature …, 2018 - nature.com
Hepatitis E virus (HEV) infection, particularly HEV genotype 1 (HEV-1), can result in
fulminant hepatic failure and severe placental diseases, but mechanisms underlying …

Evolution of two major Zika virus lineages: implications for pathology, immune response, and vaccine development

JT Beaver, N Lelutiu, R Habib, I Skountzou - Frontiers in immunology, 2018 - frontiersin.org
Zika virus (ZIKV) became a public health emergency of global concern in 2015 due to its
rapid expansion from French Polynesia to Brazil, spreading quickly throughout the …

Zika virus vaccines

P Abbink, KE Stephenson, DH Barouch - Nature Reviews Microbiology, 2018 - nature.com
The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating
consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome …