Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …

Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

Cancer stem cells that display tumor-initiating properties have recently been identified in
several distinct types of malignancies, holding promise for more effective therapeutic …

The ETS gene family is frequently involved in chromosome translocations that cause human
cancer, including prostate cancer, leukemia, and sarcoma. However, the mechanisms by …

Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …

Background Chromosomal translocations generating oncogenic transcription factors are the
hallmark of a variety of tumors, including many sarcomas. Ewing sarcoma family of tumors …

Tumor development is a complex process resulting from interplay between mutations in
oncogenes and tumor suppressors, host susceptibility factors, and cellular context. Great …

Abstract Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant
neoplasms affecting children and young adults. We performed a study to typify the …

Many soft tissue sarcomas have chromosomal translocations with resultant formation of new
fusion genes. Among the genes that can be rearranged, the EWSR 1 gene has been …

The fusion between EWS and ETS family members is a key oncogenic event in Ewing
tumors and important EWS-FLI1 target genes have been identified. However, until now, the …