Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Activation of the peripheral immune system elicits a coordinated response from the central
nervous system. Key to this immune to brain communication is that glia, microglia, and …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Animal studies are now showing the exciting potential to achieve significant functional
recovery following central nervous system (CNS) injury by manipulating both the inefficient …

The past 20 years have seen a gain in knowledge on microglia biology and microglia
functions in disease that exceeds the expectations formulated when the microglia “immune …

Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

During the transition from acute to chronic stages of recovery after spinal cord injury (SCI),
there is an evolving state of immunologic dysfunction that exacerbates the problems …

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects
thousands of human beings, and the pathologic changes after injury have been a hot spot …

[Frontiers in Bioscience 14, 5291-5338, June 1, 2009] 5291 Neurobiology of depression,
fibromyalgia and neuropathic pain Vladimi Page 1 [Frontiers in Bioscience 14, 5291-5338, June …