DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …

Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …

Poly (ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA
breaks. Surprisingly, however, we show that most if not all endogenous poly (ADP-ribose) is …

Damage to DNA bases occurs continuously in cells as a result of the intrinsic instability of
nucleic acids and because of the presence of intracellular and environmental genotoxins. As …

Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-
dependent repair and classical nonhomologous end-joining. Recent studies have identified …

Co-transcriptional RNA-DNA hybrids can not only cause DNA damage threatening genome
integrity but also regulate gene activity in a mechanism that remains unclear. Here, we show …

Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …

DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …

The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …

X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base
excision repair and single strand break repair, and is also a participant in other repair …