Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Colistin is regarded as a last-line drug against serious infections caused by multidrug-
resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin …

In the face of the alarming rise in global antimicrobial resistance, only a handful of novel
antibiotics have been developed in recent decades, necessitating innovations in therapeutic …

For many years, ionophores have been used to control coccidiosis in poultry. However,
misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory
response to infection. Effective treatment of bacterial sepsis remains a paramount clinical …

Streptococcus pneumoniae is the primary cause of community-acquired bacterial
pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40 …

Although new-generation antimicrobials, in particular β-lactam/β-lactamase inhibitors, have
largely replaced polymyxins in carbapenem-resistant Gram-negative bacterial infections …

Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion transporter
required for epithelial homeostasis in the lung and other organs, with CFTR mutations …

Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue.
Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are …