Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures
Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …
optimize behavior and physiology in humans. Relatively recent changes to our …
Circadian disruption: What do we actually mean?
C Vetter - European Journal of Neuroscience, 2020 - Wiley Online Library
The circadian system regulates physiology and behavior. Acute challenges to the system,
such as those experienced when traveling across time zones, will eventually result in re …
such as those experienced when traveling across time zones, will eventually result in re …
Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms
ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
Dosing-time makes the poison: circadian regulation and pharmacotherapy
R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
The mammalian circadian clock and its entrainment by stress and exercise
The mammalian circadian clock regulates day–night fluctuations in various physiological
processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus …
processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus …
Roles of neuropeptides, VIP and AVP, in the mammalian central circadian clock
D Ono, K Honma, S Honma - Frontiers in neuroscience, 2021 - frontiersin.org
In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of
the hypothalamus. Individual SCN cells exhibit intrinsic oscillations, and their circadian …
the hypothalamus. Individual SCN cells exhibit intrinsic oscillations, and their circadian …
Off the clock: from circadian disruption to metabolic disease
E Maury - International journal of molecular sciences, 2019 - mdpi.com
Circadian timekeeping allows appropriate temporal regulation of an organism's internal
metabolism to anticipate and respond to recurrent daily changes in the environment …
metabolism to anticipate and respond to recurrent daily changes in the environment …
Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian
pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older …
pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older …
Synchronization of the mammalian circadian timing system: light can control peripheral clocks independently of the SCN clock: alternate routes of entrainment …
A vast network of cellular circadian clocks regulates 24‐hour rhythms of behavior and
physiology in mammals. Complex environments are characterized by multiple, and often …
physiology in mammals. Complex environments are characterized by multiple, and often …
The circadian system: a regulatory feedback network of periphery and brain
FN Buijs, L León-Mercado, M Guzmán-Ruiz… - …, 2016 - journals.physiology.org
Circadian rhythms are generated by the autonomous circadian clock, the suprachiasmatic
nucleus (SCN), and clock genes that are present in all tissues. The SCN times these …
nucleus (SCN), and clock genes that are present in all tissues. The SCN times these …