The limited penetration of nanoparticles in primary tumors and metastases remains a great
challenge for effective treatment of tumor metastasis. This review outlines the current …

Nanomedicines can effectively penetrate tumor sites compared to traditionally used drugs.
However, effective drugs that reach the interior of tumors remain limited. Based on studies of …

Background Extracellular vesicles (EVs) are attractive candidate drug delivery systems due
to their ability to functionally transport biological cargo to recipient cells. However, the …

Abnormal tumor vessels impede the transport and distribution of chemotherapeutics,
resulting in low drug concentration at tumor sites and compromised drug efficacy …

Vascular normalization (VN) by anti-angiogenic factors may be efficacious for improving
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …

The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for
peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic …

Lanthanide-doped upconverting nanoparticles (UCNPs) are well-known for their inherent
ability to convert low energy near-infrared (NIR) excitation wavelengths into higher energy …

Tumor-induced angiogenesis leads to the development of leaky tumor vessels devoid of
structural and morphological integrity. Due to angiogenesis, elevated interstitial fluid …

Implementation of effective cancer treatment strategies requires consideration of how the
spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor …

This study numerically analyzes the fluid flow and solute transport in a solid tumor to
comprehensively examine the consequence of normalization induced by anti-angiogenic …