Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …

Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell
with the necessary energy and cofactors to promote cell survival and proliferation. A …

Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic
pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental …

We present a quantitative model to demonstrate that coclustering multiple enzymes into
compact agglomerates accelerates the processing of intermediates, yielding the same …

The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

Flavonoids are a class of plant specialized metabolites with more than 6,900 known
structures and play important roles in plant survival and reproduction. These metabolites are …

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …

The organization of metabolic multienzyme complexes has been hypothesized to benefit
metabolic processes and provide a coordinated way for the cell to regulate metabolism …

Most knowledge of protein structure and function is derived from experiments performed with
purified protein resuspended in dilute, buffered solutions. However, proteins function in the …