Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

T Hainmueller, M Bartos - Nature Reviews Neuroscience, 2020 - nature.com
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

Regulation and function of adult neurogenesis: from genes to cognition

JB Aimone, Y Li, SW Lee… - Physiological …, 2014 - journals.physiology.org
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Adult-born dentate granule cells promote hippocampal population sparsity

SB McHugh, V Lopes-dos-Santos, GP Gava… - Nature …, 2022 - nature.com
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …

Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells

Y Senzai, G Buzsáki - Neuron, 2017 - cell.com
The hippocampal dentate gyrus is often viewed as a segregator of upstream information.
Physiological support for such function has been hampered by a lack of well-defined …

The mechanisms for pattern completion and pattern separation in the hippocampus

ET Rolls - Frontiers in systems neuroscience, 2013 - frontiersin.org
The mechanisms for pattern completion and pattern separation are described in the context
of a theory of hippocampal function in which the hippocampal CA3 system operates as a …

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

W Deng, JB Aimone, FH Gage - Nature reviews neuroscience, 2010 - nature.com
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

MA Kheirbek, KC Klemenhagen, A Sahay… - Nature neuroscience, 2012 - nature.com
Although an influence of adult neurogenesis in mediating some of the effects of
antidepressants has received considerable attention in recent years, much less is known …

A computational theory of hippocampal function, and tests of the theory: new developments

RP Kesner, ET Rolls - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
The aims of the paper are to update Rolls' quantitative computational theory of hippocampal
function and the predictions it makes about the different subregions (dentate gyrus, CA3 and …

Synaptic mechanisms of pattern completion in the hippocampal CA3 network

SJ Guzman, A Schlögl, M Frotscher, P Jonas - Science, 2016 - science.org
The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3
synapses are thought to be the subcellular substrate of pattern completion. However, the …

Pyramidal cell-interneuron circuit architecture and dynamics in hippocampal networks

DF English, S McKenzie, T Evans, K Kim, E Yoon… - Neuron, 2017 - cell.com
Excitatory control of inhibitory neurons is poorly understood due to the difficulty of studying
synaptic connectivity in vivo. We inferred such connectivity through analysis of spike timing …