Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …

Invasive fungal diseases are rare in individuals with intact immunity. This, together with the
fact that there are only a few species that account for most mycotic diseases, implies a …

Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

A robust and efficient cellular response to lysosomal membrane damage prevents leakage
from the lysosome lumen into the cytoplasm. This response is understood to happen through …

The egress of Candida hyphae from macrophages facilitates immune evasion, but it also
alerts macrophages to infection and triggers inflammation. To better define the mechanisms …

Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …

Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …