Steroids modification for improving their biological activities is one of the most efficient and
fruitful methods to develop novel medicines. Steroids with aza-heterocycles attaching to the …

Extensive research over the last decade has resulted in a number of highly potent tubulin
polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or …

We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines
as tubulin polymerization inhibitors targeting the colchicine binding site with significantly …

Polymerization of tubulin dimers to form microtubules is one of the key events in cell
proliferation. The inhibition of this event has long been recognized as a potential treatment …

Methoxyestradiol (2ME 2), an estrogen hormone metabolite is a potential cancer
chemotherapeutic agent. Presently, it is an investigational drug under various phases of …

A series of 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives were designed,
synthesized and evaluated as potential tubulin polymerization inhibitors and for the …

Abstract The IL6/JAK2/STAT3 axis dysregulation and the related downstream pathways are
a major contributor to the progression of non-small-cell lung carcinoma (NSCLC) and mainly …

Abstract Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription
either through its association with the mediator complex or by the phosphorylation of …

Abstract A series of 1‐methyl‐1H‐indole–pyrazoline hybrids were designed, synthesized,
and biologically evaluated as potential tubulin polymerization inhibitors. Among them …

A series of novel indole‐1, 2, 4‐triazole derivatives have been designed, synthesized, and
evaluated as potential tubulin polymerization inhibitors. The top hit 12, bearing the 3, 4, 5 …