Respiratory and intestinal microbiota in pediatric lung diseases—Current evidence of the gut–lung axis

S Stricker, T Hain, CM Chao, S Rudloff - International Journal of …, 2022 - mdpi.com
The intestinal microbiota is known to influence local immune homeostasis in the gut and to
shape the developing immune system towards elimination of pathogens and tolerance …

Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility of Pseudomonas aeruginosa

E Reece, PHA Bettio, J Renwick - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is one of the most dominant pathogens in cystic fibrosis (CF)
airway disease and contributes to significant inflammation, airway damage, and poorer …

[HTML][HTML] Critically ill patients with COVID-19 show lung fungal dysbiosis with reduced microbial diversity in patients colonized with Candida spp.

E Viciani, P Gaibani, A Castagnetti, A Liberatore… - International Journal of …, 2022 - Elsevier
Background The COVID-19 pandemic has intensified interest in how the infection affects the
lung microbiome of critically ill patients and how it contributes to acute respiratory distress …

The role of the respiratory microbiome in the pathogenesis of aspiration pneumonia: Implications for diagnosis and potential therapeutic choices

NG Vallianou, A Skourtis, D Kounatidis, E Margellou… - Antibiotics, 2023 - mdpi.com
Although the lungs were considered to be sterile until recently, the advent of molecular
biology techniques, such as polymerase chain reaction, 16 S rRNA sequencing and …

Quantification of phenotypic variability of lung disease in children with cystic fibrosis

M Stahl, E Steinke, MA Mall - Genes, 2021 - mdpi.com
Cystic fibrosis (CF) lung disease has the greatest impact on the morbidity and mortality of
patients suffering from this autosomal-recessive multiorgan disorder. Although CF is a …

Insights into the Adolescent Cystic Fibrosis Airway Microbiome Using Shotgun Metagenomics

G McDermott, A Walsh, F Crispie, S Frost… - International Journal of …, 2024 - mdpi.com
Cystic fibrosis (CF) is an inherited genetic disorder which manifests primarily in airway
disease. Recent advances in molecular technologies have unearthed the diverse …

[HTML][HTML] The lower airway microbiome in paediatric health and chronic disease

S Campbell, K Gerasimidis, S Milling, AJ Dicker… - Paediatric respiratory …, 2024 - Elsevier
The advent of next generation sequencing has rapidly challenged the paediatric respiratory
physician's understanding of lung microbiology and the role of the lung microbiome in host …

Lung microbiome: new insights into bronchiectasis' outcome

A Azoicai, A Lupu, MM Alexoae, IM Starcea… - Frontiers in Cellular …, 2024 - frontiersin.org
The present treatments for bronchiectasis, which is defined by pathological dilatation of the
airways, are confined to symptom relief and minimizing exacerbations. The condition is …

Extensive microbiological respiratory tract specimen characterization in critically ill COVID‐19 patients

K Thomsen, HP Pedersen, S Iversen, L Wiese… - Apmis, 2021 - Wiley Online Library
Microbial co‐infections may contribute to the pulmonary deterioration in COVID‐19 patients
needing intensive care treatment. The present study portrays the extent of co‐infections in …

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

E Steinke, O Sommerburg, SY Graeber… - Frontiers in …, 2023 - frontiersin.org
Background Lung disease as major cause for morbidity in patients with cystic fibrosis (CF)
starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype …