Introduction Despite a large preclinical literature demonstrating neuroprotective effects of
estrogen, use of menopausal hormone therapy (HT) for Alzheimer's disease (AD) risk …

Ovarian hormones, particularly 17β-estradiol, are involved in numerous neurophysiological
and neurochemical processes, including those subserving cognitive function. Estradiol plays …

Objective Women have a higher lifetime risk of Alzheimer's disease (AD) than men. Among
cognitively normal (CN) older adults, women exhibit elevated tau positron emission …

Summary Background Alzheimer's Disease, the leading cause of dementia, is over-
represented in females. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk …

We assessed sex differences in amyloid-and tau-PET retention in 119 amyloid positive
patients with mild cognitive impairment or Alzheimer's disease (AD) dementia. Patients …

Abstract Purpose of Review The prevalence of Alzheimer's disease and related dementias is
greater in women compared to men. We provide a review of female sex-specific risk factors …

Neurological aging is frequently viewed as a linear process of decline, whereas in reality, it
is a dynamic non-linear process. The dynamic nature of neurological aging is exemplified …

Purpose Off-target binding in the skull and meninges is observed in some subjects
undergoing tau positron emission tomography (PET) and could potentially differ between …

The rapid and continual development of a number of radiopharmaceuticals targeting
different receptor, enzyme and small molecule systems has fostered Positron Emission …

Off-target binding of [18F] flortaucipir (FTP) can complicate quantitative PET analyses. An
underdiscussed off-target region is the skull. Here, we characterize how often FTP skull …