CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Shared and independent roles of CGRP and PACAP in migraine pathophysiology

A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

The Registry for Migraine (REFORM) study: methodology, demographics, and baseline clinical characteristics

WK Karlsson, H Ashina, CK Cullum… - The Journal of …, 2023 - Springer
Background Erenumab has demonstrated effectiveness for prevention of migraine attacks,
but the treatment is costly, and a considerable proportion of patients do not respond to it. The …

Serum VEGF and CGRP Biomarkers: Relationships with Pain Intensity, Electric Pain, Pressure Pain Threshold, and Clinical Symptoms in Fibromyalgia—An …

RM Tapia-Haro, F Molina, A Rus… - International Journal of …, 2023 - mdpi.com
Fibromyalgia (FM) is a multifactorial syndrome, mainly characterized by chronic widespread
pain, whose physiopathology is yet to be determined. Reliable biomarkers for FM and how …

Shedding Valuable Tears: Tear Fluid as a Promising Source of Disease Biomarkers

IS Vavilina, AA Shpak, TA Druzhkova, AB Guekht… - Neurochemical …, 2023 - Springer
The simplicity of collecting and evaluating tear fluid (TF) can potentially provide a convenient
non-invasive diagnostic tool that easily fits into a personalized approach to medicine based …

The influence of pharmacodynamics and pharmacokinetics on the antimigraine efficacy and safety of novel anti-CGRPergic pharmacotherapies: a narrative review

A González-Hernández, CM Villalón - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Migraine is a complex disorder, and its etiology is not yet fully understood. In the
last 40 years, calcitonin gene-related peptide (CGRP) has been central to the understanding …

Biomarkers and Endophenotypes of Post-traumatic Headaches

JL Kamins, R Karimi, A Hoffman, ML Prins… - Current Pain and …, 2024 - Springer
Abstract Purpose of Review To review existing literature on biomarkers for post-traumatic
headache (PTH). Recent Findings Preclinical models and clinical findings have started to …

Are we closer to achieving precision medicine for migraine treatment? A narrative review

K Ihara, F Casillo, A Dahshan, H Genç… - …, 2024 - journals.sagepub.com
Background The term 'precision medicine'encompasses strategies to optimize diagnosis
and outcome prediction and to tailor treatment for individual patients, in consideration of …

Monoclonal anti-CGRP antibodies in post-menopausal women: a real-life study

S Guerzoni, C Baraldi, D Brovia, MM Cainazzo… - Acta Neurologica …, 2023 - Springer
Introduction Migraine usually ameliorates after menopause. However, 10–29% of women
still experience migraine attacks after menopause, especially if menopause is surgical. The …

[PDF][PDF] Investigation of calcitonin-gene related peptide levels in tear fluid during nitroglycerin induced migraine attacks

MC Khorsandian - 2023 - edoc.ub.uni-muenchen.de
Abstract in German (Zusammenfassung) Migräne ist eine primäre Kopfschmerzerkrankung,
die sich durch wiederholte, häufig einseitige, schwere Kopfschmerzen über 4-72h äußert …