Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …

Diabetic wound is one of the most intractable chronic wounds that is prone to bacterial
infection. Hypoxia is an important feature in its microenvironment. However, it is challenging …

Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

Globally, millions of people die of microbial infection-related diseases every year. The more
terrible situation is that due to the overuse of antibiotics, especially in developing countries …

Pseudomonas aeruginosa lung infections are a major cause of death in cystic fibrosis and
hospitalized patients. Treating these infections is becoming difficult due to the emergence of …

Highlights•Cells are covered by a dense, protective glycan layer, the glycocalyx.•Viruses,
bacteria and fungi exploit these glycans to gain entry to the host.•The mucus layer covering …

DNA-encoded chemical library technology (DECL or DEL) has become an important pillar
for small-molecule drug discovery. The technology rapidly identifies small-molecule hits for …

Chronic Pseudomonas aeruginosa infections are characterized by biofilm formation, a major
virulence factor of P. aeruginosa and cause of extensive drug resistance. Fluoroquinolones …

Bacterial adhesion, biofilm formation and host cell invasion of the ESKAPE pathogen
Pseudomonas aeruginosa require the tetravalent lectins LecA and LecB, which are …