For more than four decades, the free-living nematode Caenorhabditis elegans has been
extensively used in anthelmintic research. Classic genetic screens and heterologous …

Drug discovery and drug target identification are two intimately linked facets of intervention
strategies aimed at effectively combating pathological conditions in humans. Simple model …

Background Globodera pallida is a devastating pathogen of potato crops, making it one of
the most economically important plant parasitic nematodes. It is also an important model for …

Infections from parasitic nematodes (or roundworms) contribute to a significant disease
burden and productivity losses for humans and livestock. The limited number of …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast
synaptic transmission in the insect nervous system and are targets of a major group of …

We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre-
and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the …

In the nematode Caenorhabditis elegans, cholinergic motor neurons stimulate muscle
contraction as well as activate GABAergic motor neurons that inhibit contraction of the …

Here we review molecular information related to resistance to the cholinergic anthelmintics
in nematodes. The amount of molecular information available varies between the nematode …

Treatment of parasitic nematode infections in humans and livestock relies on a limited
arsenal of anthelmintic drugs that have historically reduced parasite burdens. However …

The nematode, Caenorhabditis elegans, possesses the most extensive known superfamily
of cys-loop ligand-gated ion channels (cys-loop LGICs) consisting of 102 subunit-encoding …