The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …

Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-d-
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …

Optimal retinal neuronal cell function requires an appropriate, tightly regulated environment,
provided by cellular barriers, which separate functional compartments, maintain their …

Excitotoxicity, defined as excessive exposure to the neurotransmitter glutamate or
overstimulation of its membrane receptors, has been implicated as one of the key factors …

Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic
neuropathy in patients over the age of 50 and is the second most common cause of …

The burden of irreversible vision loss from Glaucoma continues to rise. While the disease
pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk …

Müller glia can serve as a source of new neurons after retinal damage in both fish and birds.
Investigations of regeneration in the mammalian retina in vitro have provided some …

Normal vision depends on the normal function of retinal neurons, so vision loss in diabetes
must ultimately be explained in terms of altered neuronal function. However, to date …

The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …