Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

KO Alfarouk, CM Stock, S Taylor, M Walsh… - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Systems chronotherapeutics

A Ballesta, PF Innominato, R Dallmann, DA Rand… - Pharmacological …, 2017 - ASPET
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

VS Ayyar, S Sukumaran - Journal of pharmacokinetics and …, 2021 - Springer
Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining,
entrainable, and oscillatory manner, and orchestrate a wide range of molecular …

Temperature desynchronizes sugar and organic acid metabolism in ripening grapevine fruits and remodels their transcriptome

M Rienth, L Torregrosa, G Sarah, M Ardisson… - BMC Plant …, 2016 - Springer
Background Fruit composition at harvest is strongly dependent on the temperature during
the grapevine developmental cycle. This raises serious concerns regarding the …

The circadian clock in white and brown adipose tissue: mechanistic, endocrine, and clinical aspects

O Froy, M Garaulet - Endocrine reviews, 2018 - academic.oup.com
Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

Chronopharmacology of glucocorticoids

ML Scherholz, N Schlesinger, IP Androulakis - Advanced drug delivery …, 2019 - Elsevier
Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive,
and cognitive signaling processes, playing an important role in homeostasis and …

Cycled light in the intensive care unit for preterm and low birth weight infants

I Morag - Cochrane Database of Systematic Reviews, 2016 - cochranelibrary.com
Cycled light in the intensive care unit for preterm and low birth weight infants - Morag, I - 2016 |
Cochrane Library Skip to Content Cookies Our site uses cookies to improve your experience …

EGCG ameliorates high‐fat–and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

Y Mi, G Qi, R Fan, Q Qiao, Y Sun, Y Gao… - The FASEB …, 2017 - Wiley Online Library
Obesity, which is caused by an energy imbalance between calorie intake and consumption,
has become a major international health burden. Obesity increases the risk of insulin …

Circadian nature of immune function

RW Logan, DK Sarkar - Molecular and cellular endocrinology, 2012 - Elsevier
The primary physiological role of the circadian system is to synchronize and coordinate
organ systems, particularly in response to dynamics in the environment. The immune system …

[HTML][HTML] Down-regulation of BMAL1 by MiR-494-3p promotes hepatocellular carcinoma growth and metastasis by increasing GPAM-mediated lipid biosynthesis

Y Yang, T Yang, Z Zhao, H Zhang, P Yuan… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The circadian clock confers daily rhythmicity to many crucial biological processes and
behaviors and its disruption is closely associated with carcinogenesis in several types of …