The accurate repair of DNA is critical for genome stability and cancer prevention. DNA
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

Partner and localizer of BRCA2 (PALB2) is vital for homologous recombination (HR) repair
in response to DNA double-strand breaks (DSBs). PALB2 functions as a tumor suppressor …

Mutations in homologous recombination (HR) genes, including BRCA1, BRCA2, and the
RAD51 paralog RAD51C, predispose to tumorigenesis and sensitize cancers to DNA …

Background It is unclear whether germline breast cancer susceptibility gene mutations affect
breast cancer related outcomes. We wanted to evaluate mutation patterns in 20 breast …

Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior
and poor prognosis. Genomic sequencing has detected a distinctive mutational portrait of …

Treatment of triple negative breast cancer (TNBC) is a clinically challenging problem due to
intriguing clinical and pathologic features of TNBC and natural or induced resistance to …

Key Clinical Message Germline pathogenic variants (PV) of the PALB2 tumor suppressor
gene are associated with an increased risk of breast, pancreatic, and ovarian cancer. In …

As a clinically heterogeneous subtype of breast cancer, triple‑negative breast cancer
(TNBC) is associated with a poor clinical outcome and a high relapse rate. Conventional …

Altered metabolism in tumor cells has been a focus of cancer research for as long as a
century but has remained controversial and vague due to an inhomogeneous overall …