Genomics of hypertension: the road to precision medicine

S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement

G Mantovani, M Bastepe, D Monk… - Nature Reviews …, 2018 - nature.com
Abstract This Consensus Statement covers recommendations for the diagnosis and
management of patients with pseudohypoparathyroidism (PHP) and related disorders …

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

M Vujkovic, JM Keaton, JA Lynch, DR Miller, J Zhou… - Nature …, 2020 - nature.com
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …

Genetics of blood lipids among~ 300,000 multi-ethnic participants of the Million Veteran Program

D Klarin, SM Damrauer, K Cho, YV Sun, TM Teslovich… - Nature …, 2018 - nature.com
Abstract The Million Veteran Program (MVP) was established in 2011 as a national research
initiative to determine how genetic variation influences the health of US military veterans …

2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents

E Lurbe, E Agabiti-Rosei, JK Cruickshank… - Journal of …, 2016 - journals.lww.com
2016 European Society of Hypertension guidelines for the man... : Journal of Hypertension 2016
European Society of Hypertension guidelines for the management of high blood pressure in …

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

A Giri, JN Hellwege, JM Keaton, J Park, C Qiu… - Nature …, 2019 - nature.com
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

A map of human circular RNAs in clinically relevant tissues

PG Maass, P Glažar, S Memczak, G Dittmar… - Journal of molecular …, 2017 - Springer
Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in
all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class …

Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension

IAM Brown, L Diederich, ME Good… - … , and vascular biology, 2018 - Am Heart Assoc
Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

D Klarin, QM Zhu, CA Emdin, M Chaffin, S Horner… - Nature …, 2017 - nature.com
UK Biobank is among the world's largest repositories for phenotypic and genotypic
information in individuals of European ancestry. We performed a genome-wide association …

[HTML][HTML] Clinical relevance of systematic phenotyping and exome sequencing in patients with short stature

NN Hauer, B Popp, E Schoeller, S Schuhmann… - Genetics in …, 2018 - Elsevier
Purpose Short stature is a common condition of great concern to patients and their families.
Mostly genetic in origin, the underlying cause often remains elusive due to clinical and …