Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Natural products as platforms to overcome antibiotic resistance

SE Rossiter, MH Fletcher, WM Wuest - Chemical reviews, 2017 - ACS Publications
Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

Quorum-sensing regulation in staphylococci—an overview

KY Le, M Otto - Frontiers in microbiology, 2015 - frontiersin.org
Staphylococci are frequent human commensals and some species can cause disease.
Staphylococcus aureus in particular is a dangerous human pathogen. In staphylococci, the …

Near-infrared light II-assisted rapid biofilm elimination platform for bone implants at mild temperature

G Zhang, Y Yang, J Shi, X Yao, W Chen, X Wei… - Biomaterials, 2021 - Elsevier
Light-triggered therapy is a prospective method to combat implant-associated infection but
near-infrared I (NIR-I) light has insufficient penetrating ability in tissues and local …

Staphylococcus aureus pathogenesis in diverse host environments

D Balasubramanian, L Harper, B Shopsin… - Pathogens and …, 2017 - academic.oup.com
Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Regulation of virulence in Staphylococcus aureus: molecular mechanisms and remaining puzzles

B Wang, TW Muir - Cell chemical biology, 2016 - cell.com
The agr locus encodes a quorum-sensing (QS) circuit required for the virulence of a
spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for …

[HTML][HTML] Role of quorum sensing in bacterial infections

I Castillo-Juárez, T Maeda… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to
coordinate the expression of several collective traits, including the production of multiple …

Thinking outside the box—novel antibacterials to tackle the resistance crisis

M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …