Avidity in antibody effector functions and biotherapeutic drug design

SC Oostindie, GA Lazar, J Schuurman… - Nature Reviews Drug …, 2022 - nature.com
Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

Complexity of viral epitope surfaces as evasive targets for vaccines and therapeutic antibodies

NL Miller, R Raman, T Clark… - Frontiers in …, 2022 - frontiersin.org
The dynamic interplay between virus and host plays out across many interacting surfaces as
virus and host evolve continually in response to one another. In particular, epitope-paratope …

AB cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses

Y Yang, RS Treger, J Hernandez-Bird, P Lu… - Science …, 2024 - science.org
Endogenous retroviruses (ERVs), comprising a substantial portion of the vertebrate genome,
are remnants of ancient genetic invaders. ERVs with near-intact coding potential reactivate …

Impact of glycosylation on viral vaccines

A Lembo, A Molinaro, C De Castro, F Berti… - Carbohydrate …, 2024 - Elsevier
Glycosylation is the most prominent modification important for vaccines and its specific
pattern depends on several factors that need to be considered when developing a new …

Multisite Partial Glycosylation Approach for Preparation of Biologically Relevant Oligomannosyl Branches Contribute to Lectin Affinity Analysis

R Usui, A Koizumi, K Nitta, T Kuribara… - The Journal of Organic …, 2023 - ACS Publications
High-mannose-type glycans play essential biological roles, eg, immune response and
glycoprotein quality control, and preparing a series of oligomannosyl branches of high …