The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

Natural compounds, in recent years, have attracted significant attention for their use in the
prevention and treatment of diverse chronic diseases as they are devoid of major toxicities …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …

Telomeres, the protective structures of chromosome ends are gradually shortened by each
cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the …