Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …

Many eukaryotic cells regulate their polarity and motility in response to external chemical
cues. While we know many of the linear connections that link receptors with downstream …

In both randomly moving Dictyostelium and mammalian cells, phosphatidylinositol (3, 4, 5)-
trisphosphate and F-actin are known to propagate as waves at the membrane and act to …

Cellulose nanocrystals (CNCs) are widely studied as reinforcing fillers for polymers. In many
cases the mechanical properties of polymer/CNC nanocomposites do not match the …

Migrating cells need to coordinate distinct leading and trailing edge dynamics but the
underlying mechanisms are unclear. Here, we combine experiments and mathematical …

Cells move through perpetual protrusion and retraction cycles at the leading edge. These
cycles are coordinated with substrate adhesion and retraction of the cell rear. We tracked …

We propose a new computation-based approach for elucidating how signaling molecules
are decoded in cell migration. In this approach, we performed FRET time-lapse imaging of …

Helena C. Junqueira1, Mauricio Baptista2, Rosangela Itri1. 1Physics Institute-University of
Sao Paulo, Sao Paulo, Brazil, 2Chemistry Institute-University of Sao Paulo, Sao Paulo …

The small molecule APR‐246 (PRIMA‐1MET) is a novel drug that restores the activity of
mutated and unfolded TP53 protein. However, the mechanisms of action and potential off …

Cell migration is central to many developmental, physiologic and pathological processes,
including cancer progression. The Ral GTPases (RalA and RalB) which act down-stream the …