Circular RNAs: biogenesis, function and role in human diseases

J Greene, AM Baird, L Brady, M Lim… - Frontiers in molecular …, 2017 - frontiersin.org
Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike
linear RNAs, form covalently closed continuous loops and act as gene regulators in …

Interaction and cross-talk between non-coding RNAs

S Yamamura, M Imai-Sumida, Y Tanaka… - Cellular and molecular …, 2018 - Springer
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and
functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a …

Human long noncoding RNA interactome: detection, characterization and function

M Kazimierczyk, MK Kasprowicz, ME Kasprzyk… - International journal of …, 2020 - mdpi.com
The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Tumor-associated macrophages as multifaceted regulators of breast tumor growth

MT Munir, MK Kay, MH Kang, MM Rahman… - International journal of …, 2021 - mdpi.com
Breast cancer is the most commonly occurring cancer in women of Western countries and is
the leading cause of cancer-related mortality. The breast tumor microenvironment contains …

TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes

M Zhao, P Kim, R Mitra, J Zhao, Z Zhao - Nucleic acids research, 2016 - academic.oup.com
Tumor suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth. A
knowledgebase with the systematic collection and curation of TSGs in multiple cancer types …

Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring

A McGuire, JAL Brown, MJ Kerin - Cancer and metastasis reviews, 2015 - Springer
Breast cancer affects approximately 12% women worldwide and results in 14% of all cancer-
related fatalities. Breast cancer is commonly categorized into one of four main subtypes …

Genetic variation in microRNA networks: the implications for cancer research

BM Ryan, AI Robles, CC Harris - Nature reviews cancer, 2010 - nature.com
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …

Micro-RNA: The darkhorse of cancer

M Budakoti, AS Panwar, D Molpa, RK Singh… - Cellular signalling, 2021 - Elsevier
The discovery of micro RNAs (miRNA) in cancer has opened up new vistas for researchers
in recent years. Micro RNAs area set of small, endogenous, highly conserved, non-coding …

[HTML][HTML] The structure of human argonaute-2 in complex with miR-20a

E Elkayam, CD Kuhn, A Tocilj, AD Haase, EM Greene… - Cell, 2012 - cell.com
Argonaute proteins lie at the heart of the RNA-induced silencing complex (RISC), wherein
they use small RNA guides to recognize targets. Initial insight into the architecture of …

Matrix Metalloproteinases: A challenging paradigm of cancer management

A Alaseem, K Alhazzani, P Dondapati, S Alobid… - Seminars in cancer …, 2019 - Elsevier
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …