This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Major features of the transcellular signaling mechanism responsible for endothelium-
dependent regulation of vascular smooth muscle tone are unresolved. We identified local …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Endothelium‐dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in
small resistance arteries and thus an important modulator of blood pressure and flow. As the …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …