Engineering universal cells that evade immune detection

R Lanza, DW Russell, A Nagy - Nature Reviews Immunology, 2019 - nature.com
The prospect of transplanting cells and tissues without the risk of immune rejection or the
need for powerful immunosuppressive drugs is the 'holy grail'of transplantation medicine …

Maintenance management and eradication of established aquatic invaders

D Simberloff - Hydrobiologia, 2021 - Springer
Although freshwater invasions have not been targeted for maintenance management or
eradication as often as terrestrial invasions have, attempts to do so are frequent. Failures as …

Massive gene presence-absence variation shapes an open pan-genome in the Mediterranean mussel

M Gerdol, R Moreira, F Cruz, J Gómez-Garrido… - Genome biology, 2020 - Springer
Abstract Background The Mediterranean mussel Mytilus galloprovincialis is an ecologically
and economically relevant edible marine bivalve, highly invasive and resilient to biotic and …

Centuries of genome instability and evolution in soft-shell clam, Myaarenaria, bivalve transmissible neoplasia

SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …

The evolution of two transmissible cancers in Tasmanian devils

MR Stammnitz, K Gori, YM Kwon, E Harry, FJ Martin… - Science, 2023 - science.org
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …

Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts

J Harding, K Vintersten-Nagy, H Yang… - Nature Biomedical …, 2024 - nature.com
The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the
advancement of cell therapies. Here we show that the overexpression of eight …

Contemporary demographic reconstruction methods are robust to genome assembly quality: a case study in Tasmanian devils

AH Patton, MJ Margres, AR Stahlke… - Molecular biology …, 2019 - academic.oup.com
Reconstructing species' demographic histories is a central focus of molecular ecology and
evolution. Recently, an expanding suite of methods leveraging either the sequentially …

Cancer in wildlife: patterns of emergence

PA Pesavento, D Agnew, MK Keel… - Nature Reviews Cancer, 2018 - nature.com
Cancer is ubiquitous in wildlife, affecting animals from bivalves to pachyderms and
cetaceans. Reports of increasing frequency demonstrate that neoplasia is associated with …

sigfit: flexible Bayesian inference of mutational signatures

K Gori, A Baez-Ortega - bioRxiv, 2018 - biorxiv.org
The premise of mutational signature analysis is that genomes acquire somatic mutations
through the collective action of discrete mutational processes, and its aim is to infer the …

Lifetime cancer prevalence and life history traits in mammals

AM Boddy, LM Abegglen, AP Pessier… - … medicine, and public …, 2020 - academic.oup.com
Background Cancer is a common diagnosis in many mammalian species, yet they vary in
their vulnerability to cancer. The factors driving this variation are unknown, but life history …