ATP-Dependent Steps in Peroxisomal Protein Import

HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

Mechanisms of protein targeting to lipid droplets: A unified cell biological and biophysical perspective

R Dhiman, S Caesar, AR Thiam, B Schrul - Seminars in Cell & …, 2020 - Elsevier
Lipid droplets (LDs), or oil bodies in plants, are specialized organelles that primarily serve
as hubs of cellular metabolic energy storage and consumption. These ubiquitous …

Protein import into peroxisomes occurs through a nuclear pore–like phase

Y Gao, ML Skowyra, P Feng, TA Rapoport - Science, 2022 - science.org
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …

Comparative genomics of peroxisome biogenesis proteins: making sense of the PEX proteins

RLM Jansen, C Santana-Molina… - Frontiers in cell and …, 2021 - frontiersin.org
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a
comparative genomics approach, we clarify the evolutionary relationships between the 37 …

[HTML][HTML] Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy

J Zheng, X Chen, Q Liu, G Zhong, M Zhuang - Journal of Cell Biology, 2021 - rupress.org
Mitochondria and peroxisomes are independent but functionally closely related organelles.
A few proteins have been characterized as dual-organelle locating proteins with distinct or …

Peroxisome function relies on organelle-associated mRNA translation

N Dahan, YS Bykov, EA Boydston, A Fadel, Z Gazi… - Science …, 2022 - science.org
Crucial metabolic functions of peroxisomes rely on a variety of peroxisomal membrane
proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with …

The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

E Nuebel, JT Morgan, S Fogarty, JM Winter… - EMBO …, 2021 - embopress.org
Peroxisomal biogenesis disorders (PBDs) are genetic disorders of peroxisome biogenesis
and metabolism that are characterized by profound developmental and neurological …

Glycine regulates lipid peroxidation promoting porcine oocyte maturation and early embryonic development

L Gao, C Zhang, Y Zheng, D Wu, X Chen… - Journal of Animal …, 2023 - academic.oup.com
In vitro-cultured oocytes are separated from the follicular micro-environment in vivo and are
more vulnerable than in vivo oocytes to changes in the external environment. This …

Development of novel anti-leishmanials: the case for structure-based approaches

M Soni, JV Pratap - Pathogens, 2022 - mdpi.com
The neglected tropical disease (NTD) leishmaniasis is the collective name given to a diverse
group of illnesses caused by~ 20 species belonging to the genus Leishmania, a majority of …

[HTML][HTML] Effects of dietary selenium on immune function of spleen in mice

X Zhang, L Zhang, K Xia, J Dai, J Huang… - Journal of Functional …, 2022 - Elsevier
The effects of selenium on serum cytokines, immune cell composition and spleen proteome
in mice are still unclear. In this study, male mice were fed with selenium-containing diets for …