PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein
tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine …

Immune checkpoint inhibition (ICI) became one of the major breakthroughs in cancer
treatment over the past decade and entered into therapy within standard oncohematology …

Thyroid hormones are involved in many biological processes such as neurogenesis,
metabolism, and development. However, compounds called endocrine disruptors can alter …

The present study was aimed to develop a novel combination therapeutic strategy of gene
therapy and immunotherapy for efficiently treatment of colorectal cancer (CRC). To achieve …

Parasites belonging to the Apicomplexa phylum still represent a major public health and
world-wide socioeconomic burden that is greatly amplified by the spread of resistances …

The JAK–STAT pathway is a central communication node for various biological processes.
Its activation is characterized by phosphorylation and nuclear translocation of the …

Immunotherapy involving checkpoint blockades of inhibitory co-receptors is effective in
combating cancer. Despite this, the full range of mediators that inhibit T-cell activation and …

In the context of inflammation, T cell activation occurs by the concerted signals of the T cell
receptor (TCR), co-stimulatory receptors ligation, and a pro-inflammatory cytokine …

Pancreatic cancer is associated with a high mortality rate, and the prognosis is positively
related to immune status. In this study, we constructed a prognostic signature from survival …

Increased understanding of the modulatory pathways controlling CD8 T cell responses has
led to the formulation of successful checkpoint inhibitor-based immunotherapies against …