An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures
of the heart and large blood vessels. Environmental factors, genetic factors and their …

Background & aims Dysregulation of iron homeostasis is associated with cardiac alterations
in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy …

Iron deficiency (ID) is common during gestation and in early infancy and can alter
developmental trajectories with lasting consequences on cardiovascular health. While the …

Neural tube defects (NTDs) are among the most common birth defects, with a prevalence of
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …

Pathogenic variants in ACTN2, coding for alpha-actinin 2, are known to be rare causes of
Hypertrophic Cardiomyopathy. However, little is known about the underlying disease …

Background Congenital anomalies affect over 2% of pregnancies, with congenital heart
disease (CHD) the most common. Understanding of causal factors is limited. Micronutrients …

Iron deficiency is globally prevalent, causing an array of developmental, haematological,
immunological, neurological, and cardiometabolic impairments, and is associated with …

Fetal growth restriction (FGR) is associated with aberrant placentation and accounts for a
significant proportion of perinatal deaths. microRNAs have been shown to be dysregulated …

Long-term alterations in kidney structure and function have been observed in offspring
exposed to perinatal stressors such as iron deficiency (ID), albeit the mechanisms …