Old paradoxes and new opportunities for appetite control in obesity

L Montégut, C Lopez-Otin, C Magnan… - Trends in Endocrinology & …, 2021 - cell.com
Human obesity is accompanied by alterations in the blood concentrations of multiple
circulating appetite regulators. Paradoxically, most of the appetite-inhibitory hormones are …

Gut peptide regulation of food intake–evidence for the modulation of hedonic feeding

ORM Woodward, FM Gribble… - The Journal of …, 2022 - Wiley Online Library
The number of people living with obesity has tripled worldwide since 1975 with serious
implications for public health, as obesity is linked to a significantly higher chance of early …

[HTML][HTML] Secretin-activated brown fat mediates prandial thermogenesis to induce satiation

Y Li, K Schnabl, SM Gabler, M Willershäuser, J Reber… - Cell, 2018 - cell.com
The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non …

Effects of dietary fiber supplementation on fatty acid metabolism and intestinal microbiota diversity in C57BL/6J mice fed with a high-fat diet

X Zhai, D Lin, Y Zhao, W Li, X Yang - Journal of agricultural and …, 2018 - ACS Publications
This work was to assess possible impacts of novel insoluble fiber 8% bacterial cellulose
(BC), soluble fiber 8% konjac glucomannan (KGM), and their mixture (4% BC/4% KGM) on …

Inhibition of secretin/secretin receptor axis ameliorates NAFLD phenotypes

L Chen, N Wu, L Kennedy, H Francis, L Ceci… - …, 2021 - Wiley Online Library
Background and Aims Human NAFLD is characterized at early stages by hepatic steatosis,
which may progress to NASH when the liver displays microvesicular steatosis, lobular …

CD36 senses dietary lipids and regulates lipids homeostasis in the intestine

L Zhao, Y Li, Q Ding, Y Li, Y Chen, XZ Ruan - Frontiers in physiology, 2021 - frontiersin.org
Dietary lipids absorbed in the intestine are closely related to the development of metabolic
syndrome. CD36 is a multi-functional scavenger receptor with multiple ligands, which plays …

The Checkpoints of Intestinal Fat Absorption in Obesity

AB Engin, A Engin - Obesity and Lipotoxicity, 2024 - Springer
In this chapter, intestinal lipid transport, which plays a central role in fat homeostasis and the
development of obesity in addition to the mechanisms of fatty acids and monoacylglycerol …

Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease

T Zhou, D Kundu, J Robles-Linares, V Meadows… - Cells, 2021 - mdpi.com
Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health
disparities, particularly in the United States, as a result of cultural eating habits and lifestyle …

[HTML][HTML] Enteroendocrine regulation of nutrient absorption

HA McCauley - The Journal of Nutrition, 2020 - Elsevier
Enteroendocrine cells (EECs) in the intestine regulate many aspects of whole-body
physiology and metabolism. EECs sense luminal and circulating nutrients and respond by …

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Y Watanabe, S Fujisaka, Y Morinaga, S Watanabe… - Molecular …, 2023 - Elsevier
Objective Polyphenols have health-promoting effects, such as improving insulin resistance.
Isoxanthohumol (IX), a prenylated flavonoid found in beer hops, has been suggested to …