Serotonin receptors

DE Nichols, CD Nichols - Chemical reviews, 2008 - ACS Publications
Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Adverse cardiovascular events associated with triptans and ergotamines for treatment of migraine: systematic review of observational studies

G Roberto, E Raschi, C Piccinni, V Conti… - …, 2015 - journals.sagepub.com
Background Apart from the underlying cardiovascular (CV) risk associated with migraine,
both triptans and ergotamines can induce vasoconstriction and potentially increase the risk …

5-HT1 receptors

L Lanfumey, M Hamon - Current Drug Targets-CNS & …, 2004 - ingentaconnect.com
Among the seven classes of serotonin (5-hydroxytryptamine, 5-HT) receptorswhich have
been identified to date, the 5-HT1 class is comprised of five receptor types, with the 5-HT1A …

Calcitonin gene-related peptide and its role in migraine pathophysiology

U Arulmani, A MaassenVanDenBrink… - European journal of …, 2004 - Elsevier
Migraine is a common neurological disorder that is associated with an increase in plasma
calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from …

Cardiovascular responses produced by 5-hydroxytriptamine: a pharmacological update on the receptors/mechanisms involved and therapeutic implications

CM Villalón, D Centurión - Naunyn-Schmiedeberg's archives of …, 2007 - Springer
The complexity of cardiovascular responses produced by 5-hydroxytryptamine (5-HT,
serotonin), including bradycardia or tachycardia, hypotension or hypertension, and …

Higher-End Serotonin Receptors:  5-HT5, 5-HT6, and 5-HT7

RA Glennon - Journal of medicinal chemistry, 2003 - ACS Publications
Serotonin (5-hydroxytryptamine, 5-HT; 1) is a major neurotransmitter that is believed to
produce many of its effects via interaction at seven populations of 5-HT receptors, 5-HT1 to 5 …

Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy

C Tas, JC Joyce, HX Nguyen, P Eangoor… - Journal of Controlled …, 2017 - Elsevier
Migraine is a widespread neurological disease with negative effects on quality of life and
productivity. Moderate to severe acute migraine attacks can be treated with …

Potential role of female sex hormones in the pathophysiology of migraine

S Gupta, S Mehrotra, CM Villalón, M Perusquía… - Pharmacology & …, 2007 - Elsevier
Clinical evidence indicates that female sex steroids may contribute to the high prevalence of
migraine in women, as well as changes in the frequency or severity of migraine attacks that …

CGRP receptor antagonists: an expanding drug class for acute migraine?

A Negro, L Lionetto, M Simmaco… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Migraine afflicts approximately 11% of the population worldwide producing
substantial disability, resulting in loss of productivity both at home and at the workplace …

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

M Ala, M Ghasemi, R Mohammad Jafari… - Drug Development …, 2021 - Wiley Online Library
Sumatriptan is the first available medication from triptans family that was approved by the US
Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of …