V (D) J recombination and the evolution of the adaptive immune system
E Market, FN Papavasiliou - PLoS biology, 2003 - journals.plos.org
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The recombinase activating genes: architects of immune diversity during lymphocyte development
M Braams, K Pike-Overzet, FJT Staal - Frontiers in Immunology, 2023 - frontiersin.org
The mature lymphocyte population of a healthy individual has the remarkable ability to
recognise an immense variety of antigens. Instead of encoding a unique gene for each …
recognise an immense variety of antigens. Instead of encoding a unique gene for each …
RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons
VV Kapitonov, J Jurka - PLoS biology, 2005 - journals.plos.org
The V (D) J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and
RAG2 proteins, which are believed to have emerged approximately 500 million years ago …
RAG2 proteins, which are believed to have emerged approximately 500 million years ago …
V (D) J recombination: recent insights in formation of the recombinase complex and recruitment of DNA repair machinery
SM Christie, C Fijen, E Rothenberg - Frontiers in Cell and …, 2022 - frontiersin.org
V (D) J recombination is an essential mechanism of the adaptive immune system, producing
a diverse set of antigen receptors in developing lymphocytes via regulated double strand …
a diverse set of antigen receptors in developing lymphocytes via regulated double strand …
Regulation and Evolution of the RAG Recombinase
G Teng, DG Schatz - Advances in immunology, 2015 - Elsevier
The modular, noncontiguous architecture of the antigen receptor genes necessitates their
assembly through V (D) J recombination. This program of DNA breakage and rejoining …
assembly through V (D) J recombination. This program of DNA breakage and rejoining …
The bounty of RAGs: recombination signal complexes and reaction outcomes
PC Swanson - Immunological reviews, 2004 - Wiley Online Library
V (D) J recombination is a form of site‐specific DNA rearrangement through which antigen
receptor genes are assembled. This process involves the breakage and reunion of DNA …
receptor genes are assembled. This process involves the breakage and reunion of DNA …
Two mutually exclusive local chromatin states drive efficient V (D) J recombination
Summary Variable (V), diversity (D), and joining (J)(V (D) J) recombination is the first
determinant of antigen receptor diversity. Understanding how recombination is regulated …
determinant of antigen receptor diversity. Understanding how recombination is regulated …
Brain cell somatic gene recombination and its phylogenetic foundations
A new form of somatic gene recombination (SGR) has been identified in the human brain
that affects the Alzheimer's disease gene, amyloid precursor protein (APP). SGR occurs …
that affects the Alzheimer's disease gene, amyloid precursor protein (APP). SGR occurs …
Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations
I Khatri, MA Berkowska, EB van den Akker… - Genes & …, 2021 - nature.com
Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG
variable, diversity and joining genes of the IG heavy (IGH), kappa (IGK) and lambda (IGL) …
variable, diversity and joining genes of the IG heavy (IGH), kappa (IGK) and lambda (IGL) …
Chromatin conformation governs T-cell receptor Jβ gene segment usage
T cells play fundamental roles in adaptive immunity, relying on a diverse repertoire of T-cell
receptor (TCR) α and β chains. Diversity of the TCR β chain is generated in part by a random …
receptor (TCR) α and β chains. Diversity of the TCR β chain is generated in part by a random …