[HTML][HTML] Stapled peptides inhibitors: a new window for target drug discovery
AM Ali, J Atmaj, N Van Oosterwijk, MR Groves… - Computational and …, 2019 - Elsevier
Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …
α-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment
L Zhang, D Lin, Y Kusov, Y Nian, Q Ma… - Journal of medicinal …, 2020 - ACS Publications
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar
active-site architecture and a unique requirement for glutamine in the P1 position of the …
active-site architecture and a unique requirement for glutamine in the P1 position of the …
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
In December 2019, the first cases of infection with a novel coronavirus, SARS-CoV-2, were
diagnosed. Currently, there is no effective antiviral treatment for COVID-19. To address this …
diagnosed. Currently, there is no effective antiviral treatment for COVID-19. To address this …
A single sulfatase is required to access colonic mucin by a gut bacterium
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …
lower intestine. In the colon, secreted mucus creates a barrier that separates these …
Design principles for cyclin K molecular glue degraders
Z Kozicka, DJ Suchyta, V Focht, G Kempf… - Nature chemical …, 2024 - nature.com
Molecular glue degraders are an effective therapeutic modality, but their design principles
are not well understood. Recently, several unexpectedly diverse compounds were reported …
are not well understood. Recently, several unexpectedly diverse compounds were reported …
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …
conditionally conduct small and large cations. Such functional plasticity is presumably …
Structural mechanism of cGAS inhibition by the nucleosome
GR Pathare, A Decout, S Glück, S Cavadini… - Nature, 2020 - nature.com
The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses
following microbial infection, cellular stress and cancer. Upon activation by double-stranded …
following microbial infection, cellular stress and cancer. Upon activation by double-stranded …
Visualization of chemical modifications in the human 80S ribosome structure
SK Natchiar, AG Myasnikov, H Kratzat, I Hazemann… - Nature, 2017 - nature.com
Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification of nearly all
eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain …
eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain …