Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …

Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/
alternatively activated (M2) phenotypes following environmental signals related to …

Background Secondary progressive multiple sclerosis, for which no satisfactory treatment
presently exists, accounts for most of the disability in patients with multiple sclerosis …

Despite major advances in recent years, immunosuppressive regimens for multiple
sclerosis, rheumatoid arthritis, systemic lupus erythematosus and graft‐versus‐host disease …

Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase,
which is required for cholesterol biosynthesis, and are beneficial in the primary and …

Statins have been prescribed extensively for their cholesterol-lowering properties and
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Rho kinases (ROCKs), the first Rho effectors to be described, are serine/threonine kinases
that are important in fundamental processes of cell migration, cell proliferation and cell …

Abstract In their Point of View entitled “Experimental Allergic Encephalomyelitis: A
Misleading Model of Multiple Sclerosis,” Sriram and Steiner 1 wrote,“The most disappointing …

The endothelium is a highly metabolically active organ that is involved in many physiological
processes, including the control of vasomotor tone, barrier function, leukocyte adhesion and …