Helicobacter pylori and gastrointestinal tract adenocarcinomas

RM Peek Jr, MJ Blaser - Nature Reviews Cancer, 2002 - nature.com
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in
the stomach, only a small fraction of colonized individuals develop this common malignancy …

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

KO Alfarouk, AHH Bashir, AN Aljarbou… - Frontiers in …, 2019 - frontiersin.org
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having
immuno-modulating properties. This bacterium is an example of a microorganism inducing …

Induction of Gastric Epithelial Cell Apoptosis by Helicobacter pylori Vacuolating Cytotoxin

TL Cover, US Krishna, DA Israel, RM Peek Jr - Cancer research, 2003 - AACR
Chronic gastritis induced by Helicobacter pylori is a strong risk factor for thedevelopment of
distal gastric adenocarcinoma. A specific host response to H. pylori that may contribute to …

Attenuation of Helicobacter pylori CagA· SHP-2 signaling by interaction between CagA and C-terminal Src kinase

R Tsutsumi, H Higashi, M Higuchi, M Okada… - Journal of Biological …, 2003 - ASBMB
Helicobacter pylori (H. pylori) is a causative agent of gastric diseases ranging from gastritis
to cancer. The CagA protein is the product of thecagA gene carried among virulent H …

Multifactorial etiology of gastric cancer

J Zabaleta - Cancer Epigenetics: Methods and Protocols, 2012 - Springer
The prevalence of gastric cancer is associated with several factors including geographical
location, diet, and genetic background of the host. However, it is evident that infection with …

Regulation of apoptosis during homeostasis and disease in the intestinal epithelium

KL Edelblum, F Yan, T Yamaoka… - Inflammatory bowel …, 2006 - academic.oup.com
A single epithelial layer serves as the interface between the organism and the contents of
the gastrointestinal tract, underlining the importance of regulating cellular viability despite an …

Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma

H Brenner, V Arndt, T Stürmer… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND Helicobacter pylori infection and a positive family history of gastric
carcinoma have been identified as risk factors for the disease. It is unclear, however, to what …

pathogenesis of Helicobacter pylori‐induced gastric inflammation

DA Israel, RM Peek - Alimentary pharmacology & therapeutics, 2001 - Wiley Online Library
Helicobacter pylori causes persistent inflammation in the human stomach, yet only a minority
of persons harbouring this organism develop peptic ulcer disease or gastric malignancy. An …

Relationship between Helicobacter pylori CagA status and colorectal cancer

H Shmuely, D Passaro, A Figer, Y Niv, S Pitlik… - The American journal of …, 2001 - Elsevier
OBJECTIVES: Infection with Helicobacter pylori, particularly with strains positive for CagA
protein, increases the risk of gastric adenocarcinoma. Few studies have explored the …

Helicobacter pylori and molecular events in precancerous gastric lesions

G Nardone, A Rocco… - Alimentary pharmacology …, 2004 - Wiley Online Library
Gastric cancer can be divided into intestinal type and diffuse type that differ substantially in
epidemiology and pathogenesis. The most important aetiological factor associated both with …